Man, through his daily functioning in various systems of action, is as if "immersed" in space-time. Therefore, security should not be understood as a property of operation system, but as a hypothetical element at the interface between the system and environment. Incapacity of this system generates unreliability of the system's security and entails its destruction. The paper continues the problem of metatheoretical considerations of securitology. The author's aim is to compare the scientific disciplines which in their subject and methodological scopes are included in the latest security science and offer possibilities for using their achievements in securitological research. The main research problem is expressed in the question: what are the possibilities of applying various scientific disciplines in comprehensive security science? The course of cognitive process used deductive inference from the patterns and models of system sciences and analogy.